低分子量肝素对增生性肾炎尿白细胞介素-6的影响

为观察低分子量肝素 (LMWH)对增生性肾炎患者尿白细胞介素 - 6 (IL - 6 )的影响 ,将 2 4例经肾活检确诊的患者随机分成对照组和治疗组。治疗组在对照组基础上另给予LMWH腹部皮下注射 ,疗程均为 4周 ,采用放射免疫法测定尿IL - 6的水平。结果示 ,患者治疗前尿IL - 6水平较健康人显著增高 ;对照组和治疗组尿IL - 6水平经治疗后均较治疗前降低 ,但治疗组较对照组降低更明显。提示 ,临床上LMWH能通过对增生性肾炎患者系膜细胞增殖和系膜基质积聚的抑制作用而发挥效应。

Influence of low-molecular weight heparin on urine interleukin-6 in patients with proliferative glomerulonephritis

Objective To explore the influence of low-molecular weight heparin (LMWH) on interleukin-6 (IL-6) in patients with proliferative glomerulonephritis, 24 patients which had been distinctly diagnosed by renal biopsy were randomly divided into a control group (n=12) and a treatment group (n=12). In addition to the treatments of the control group, the patients of the treatment group were given with LMWH by hypodermic injection for four weeks. The level of urine IL-6 was detected by radioimmunoassay (RIA). The results were that the level of urine IL-6 was higher in patients than that in healthy persons (n=24); after the treatment, the level of urine IL-6 was significantly decreased both in the control and treatment group, but it was lower in the treatment group than that in the control group. The effect of LMWH on patients with proliferative glomerulonephritis may be associated with inhibiting the proliferation of mesangial cell and the accumulation of mesangial matrix.