| Development and validation of a selective and robust LC-MS/MS method for quantifying trimetazidine in human plasma |
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| 引用本文： | ZHOU Gan OUYANG Dong-sheng TAN Zhi-rong CHEN Yao GUO Dong LIU Ying-zi ZHOU Hong-hao. Development and validation of a selective and robust LC-MS/MS method for quantifying trimetazidine in human plasma[J]. 中国临床药理学与治疗学, 2007, 12(10): 1198-1199 |
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| 作者姓名： | ZHOU Gan OUYANG Dong-sheng TAN Zhi-rong CHEN Yao GUO Dong LIU Ying-zi ZHOU Hong-hao |
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| 作者单位： | Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China |
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| 摘 要： | AIM： To develop and validate a liquid chromatography-tandem mass spectrometric method （LC-MS/MS） for quantifying trimetazidine in human plasma.METHODS： Sample preparation was based on extracted using acetonitrile only. Chromatography was performed on a C18 analytical column and the retention times were 1.9 and 2.6 min for trimetazidine and cetirizine （internal standard）, respectively. The ionization was optimized using ESI （ ＋ ） and enhanced selectivity was achieved using tandem mass spectrometric analysis via two MRM functions, m/z：267→m/z： 181 and m/z：389→m/z：201 for trimetazidine and cetirizine.[第一段]
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| 关 键 词： | LC-MS/MS 人血浆 曲美他嗪 浓度测定 |
Development and validation of a selective and robust LC-MS/MS method for quantifying trimetazidine in human plasma |
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| Abstract: | |
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| Keywords: | mass spectrometry bioquivalence trimetazidine |
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