| Spermatogenic effect of Yacon tubers extracts and its constituents |
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| 引用本文： | PARK Jeong-sook YANG Jae-sik HWANG Bang-yeon HAN Kun. Spermatogenic effect of Yacon tubers extracts and its constituents[J]. 中国临床药理学与治疗学, 2007, 12(10): 1187-1187 |
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| 作者姓名： | PARK Jeong-sook YANG Jae-sik HWANG Bang-yeon HAN Kun |
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| 作者单位： | College of Pharmacy, CBITRC, Chungbuk National University, Cheongju, Heungdukgu C, aeshinclong San 12, Chungbuk 361-763, S. Korea |
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| 摘 要： | AIM： Smallanthus sonchifolius （Yacon） has been used as a food and folk medicine in the Andes region. It was screened the pharmacological effects of a 50% ethanol extract of Yacon on spermatogenesis in rats. This study is carried out to evaluate the possibility of using Yacon tubers extracts as a fertility agent to treat infertility caused by spermatogenic disorders. METHODS： The dried, pulverized Yacon tubers were extracted with 50% ethanol at 50 ℃ for 5 h under sonication. The Yacon extracts were analyzed by using HPLC system on a Kromasil C18 column （250 mm × 4.6 mm）. The Yacon tubers extracts, chlomgenic acid and ferulic acid were administrated to rats once daily by oral gavage. The number of sperm heads in the testis was assessed by counting the number of sperm heads using slight modification of the procedure reported by Toth et al （1989）.RESULTS： After administration of chlorogenic acid and Yacon tuber extracts to rat for 5 weeks, the number of sperm in epididymis were increased by 20.33% and 34.48%, respectively. The ferulie acid which was reported as a metabolite of ehlorogenie acid and constituent of Yaeon to estimate the spermatogenie activity was also administered.[第一段]
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| 关 键 词： | 雪莲薯 提取物 成分 促进作用 精子发生 |
Spermatogenic effect of Yacon tubers extracts and its constituents |
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| Abstract: | |
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| Keywords: | Smallanthus sonchifolius spermatogene-sis chlorogenic acid femlic acid fertility |
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