| 蛇毒解离素抗肿瘤研究进展 |
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| 引用本文： | 张晔,芮景.蛇毒解离素抗肿瘤研究进展[J].中国临床药理学与治疗学,2007,12(9):984-988. |
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| 作者姓名： | 张晔 芮景 |
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| 作者单位： | 皖南医学院附属弋矶山医院普外三科,芜湖,241001,安徽 |
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| 摘 要： | 细胞膜表面受体在疾病中的作用越来越受到关注,整合素就是其中之一,它在机体内通过在细胞与细胞之间、细胞与细胞外基质之间发挥黏附作用从而影响多种疾病的发生。蛇毒具有多种抗肿瘤活性成分,其中解离素的研究近年来较为深入。解离素特异性地针对整合素的黏附作用,在抗血栓、抗肿瘤等方面发挥作用,本文就蛇毒解离素的种类、抗肿瘤活性及机制、临床应用等作一综述。
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| 关 键 词： | 蛇毒 整合素 解离素 |
| 文章编号： | 1009-2501（2007）09-0984-05 |
| 修稿时间： | 2007-07-31 |
Research progress of snake venom disintegrin in treatment of tumor |
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| ZHANG Ye,RUI Jing.Research progress of snake venom disintegrin in treatment of tumor[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2007,12(9):984-988. |
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| Authors: | ZHANG Ye RUI Jing |
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| Institution: | Department of General Surgery,Affiliated Yijishan Hospital of Wannan Medical College,Wuhu 241000,Anhui,China |
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| Abstract: | The function of cellular membrane receptor has been paid more attention in many dieases.Integrin is one of them.The major function of integrin is maintaining the proper structure of tissues by organization of cell-cell and cell-extracelluar matrix tethering.The initiation and prolongation of many diseases are promoted by these receptors.Disintegrin is one important component of the snake venom.It inhibit the adhesive attraction of integrin particularly.This review summarizes the types and the biological activities of snake venom disintegrins,as well as discusses there potential clinical application of the study,such as anti-tumor,anticoagulation,and various human diseases. |
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| Keywords: | snake venom integrin disintegrin |
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