Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures |
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| Authors: | Naoto Kuroda Shin-ichi Iwamura Nokiaki Fujishima Masahiko Ohara Takashi Hirouchi Keiko Mizuno Yoshihiro Hayashi Gang-Hong Lee |
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| Institution: | (1) Departments of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, 2-13-51 Shin-honmachi, Kochi City Kochi, 780-8562, Japan;(2) Department of Internal Medicine, Kochi Red Cross Hospital, Kochi, Japan;(3) Department of Surgery, Kochi Red Cross Hospital, Kochi, Japan;(4) Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi, Japan |
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| Abstract: | A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy
was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head.
The carcinoma components contained adenocarcinoma and squamous cell carcinoma. Additionally, undifferentiated spindle or pleomorphic
cells were seen in continuity with the carcinoma component. Undifferentiated neoplastic cells with rhabdoid features and with
hyaline globule-like structures positive for PAS stain with diastase pretreatment were also observed. Immunohistochemically,
cytoplasmic inclusions corresponding to rhabdoid features showed aggregates of vimentin. Ultrastructurally, hyaline globule-like
structures corresponded to lysosomes. Finally, we report here the first case of anaplastic carcinoma of the pancreas with
hyaline globule-like structures. |
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| Keywords: | Anaplastic carcinoma Pancreas Hyaline globule-like structures Ultrastructure |
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