国产卡铂与顺铂治疗恶性卵巢肿瘤的疗效比较

采用国产卡铂和顺铂治疗恶性卵巢肿瘤６８例，Ⅰｃ期４例，Ⅱ期１１例，Ⅲ期３６例，Ⅳ期５例，复发转移病人１２例，随机分两组：卡铂用药组３７例，腹腔化疗２０例，全身化疗１７例；顺铂用药组３１例，腹腔化疗１８例，全身化疗１１例。卡铂治疗组有效率为５９％；顺铂对照组有效率为５２％，两组有效率相似（Ｐ＞０．０１）。卡铂腹腔化疗组有效率为６０％，略高于其他各组。卡铂组胃肠反应较顺铂组轻，血液系统变化与顺铂组无明显差别，对肾损伤较顺铂轻。卡铂可作为治疗晚期卵巢癌病人的一线药物。

Compare carboplatin (CP) with cisplatin (DDP) in the treatment of advanced ovarian cancer

68 patients with advanced ovarian Cancer had been treated in our hospital from June 1987 to June 1992. of them, 15 cases with stage Ⅱ, 38 cases with stage Ⅲ, 5cases with stage Ⅳ. 37 patients were treated by CP-containing regimens, 20 patience were administered by the intraperitoneal route (IP) with CF (CP+5-Fu), 17 by intravenous infusion (Ⅳ) with CVC (CP+VCR+CTX). 31 patients were treated by DDP-containing regimens. 18 by IP with PF (DDP+S-Fu), 13 by Ⅳ with PVC (DDP+VCR+CTX). The response rate was 59% to rnntaining CP regimens and 52% to containing DDP regimens. It has been demonstrated that CP produces results equivalent to those that can be achieved with DDP. In addition, gastrointeatinal reaction and renal toxicity were less severe in regimens containing CP than in regimens containing DDP. However, CP had more marked myelosuppessive effect.