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氧氟沙星和四环素对白细胞趋化性的影响
引用本文:徐兰芳 唐美玉. 氧氟沙星和四环素对白细胞趋化性的影响[J]. 西北药学杂志, 1996, 11(1): 19-20
作者姓名:徐兰芳 唐美玉
摘    要:用琼脂糖白细胞趋化法,以甲酰三肽作趋化剂检测氧氟沙星及四环素对人白细胞趋化的影响。结果显示,二药对白细胞游走都有抑制作用,其IC50为氧氟沙星2.59mg/L及四环素9.89mg/L。抗菌药物的这种作用可能在寻常痤疮治疗中起到非特异性抗炎作用。

关 键 词:氧氟沙星;四环素;白细胞趋化性;甲酰三肽

ffect of ofloxacin and tetracycline on leukocyte chemotaxis
Abstract:The effect of ofloxacin and tetracycline on humen leukocyte chemotaxiswas studied with the agarose leukocyte chemotaxis method using f-Met-Leu-Phe(fMLP).The results showed that they inhibited the leukocyte locomotion, and the IC50 was2. 59mg/L and 9. 89mg/L respectively. This effect of antibacterial drugs would probablybe nonspecific anti-inflammatory action for infective inflammation.
Keywords:ofloxacin   tetracycline   leukocyte chemotaxis   f-Met-Leu-Phe(fMLP)
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