| 阿多拉扶正霖对老龄雌性小鼠微核和肝功能的影响 |
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| 引用本文： | 陈少华,刘倩,冯福英,黄国英,邓泽前.阿多拉扶正霖对老龄雌性小鼠微核和肝功能的影响[J].海峡药学,1997(Z1). |
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| 作者姓名： | 陈少华 刘倩 冯福英 黄国英 邓泽前 |
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| 作者单位： | 中国人民解放军第四七六医院 |
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| 基金项目： | 福建省农科院提供部份资助 |
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| 摘 要： | 阿多拉扶正霖（ADL）是一种新开发的抗辐射药物，为了临床上的安全使用，特选用老龄雌性昆明种小鼠进行骨髓嗜多染红细胞微核率和肝功能的检测。结果表明，连续9天灌以ADL的老年雌性小鼠其微核率比相应的对照组降低，差异显著（P＜0．05）。ADL对小鼠的肝功能指标ALT、AST和GGT基本上无改变，差异不显著（P＞0．05）。实验结果提示，ADL对小鼠骨髓细胞不具有细胞遗传毒性，不影响肝功能，临床上使用基本安全。
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| 关 键 词： | 阿多拉扶正霖 微核 转氨酶 γ－谷氨酰转移酶同功酶 |
The Effects of Aduora on the Micronucleus and Liver Function in the Old Female Mouse |
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| Chen Shaohua, LuQian, Feng Fuying,Huang Guoying, Den zhegian.The Effects of Aduora on the Micronucleus and Liver Function in the Old Female Mouse[J].Strait Pharmaceutical Journal,1997(Z1). |
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| Authors: | Chen Shaohua LuQian Feng Fuying Huang Guoying Den zhegian |
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| Institution: | The 476th hospital of PLA |
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| Abstract: | Aduola is a new drug of antiradiation. The effects of Aduola on micronucleus of polychromatic erythrocytes of bone marrow in the old female mouse and the liver function were examined for clinical use safely, The result showed that the micronucleus rate of administrating Aduola one time a day,continuing 9 days, was lower than that of the contrast group (P<0. 05 ). There were no difference between Aduola group and contrast group on ALT, AST and GGT (P>0.05). It suggested that Aduola have no genetictoxicity and no harm to liver function. |
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| Keywords: | Aduola Micronucleus ALT AST GGT |
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