苗药防感香囊对小鼠体重和死亡率的影响

目的:观察苗药香囊对小鼠体重和死亡率的影响。方法:将60只正常昆明种雄性小鼠随机均分为香囊持续吸入组(A组)、玉屏风散阳性对照组(B组)、香囊间断吸入组(C组)、空白对照组(D组)和香囊持续吸入加玉屏风散组(E组);B、E组给予玉屏风散颗粒(20mg/10g/d)灌胃;A、C、D组给等体积生理盐水(NS)灌胃;A、E组持续吸入香囊,C组间断吸入香囊。4周后停止灌胃、吸入香囊,继续喂养小鼠11个月,观察小鼠的体重和死亡情况。结果:A、B、E组小鼠体重升高,与C、D组比较差异有统计学意义(P<0.05);A、B、E组两两比较差异无统计学意义(P>0.05);C组与D组比较差异无统计学意义(P>0.05)。A、B、E组小鼠死亡率降低,与D组比较差异有统计学意义(P<0.05),A、B、E组与C组比较差异无统计学意义(P>0.05),A、B、E组两两比较差异无统计学意义(P>0.05),C组与D组比较差异无统计学意义(P>0.05)。结论:苗药香囊对机体有保护作用,其机制需进一步研究。

The Effect of Miaoyao Anti-influenza Sachet on Weight and Death Rate

Objective:To observe the effect of Miaoyao anti-influenza sachet on weight and death rate.Methods:60 Kunming male mice were randomly divided into four groups: continuous inhaling Sachet group(group A,n = 10),Yu-Ping-Feng powder positive control group(group B,n = 10),discontinuous inhaling Sachet group(C group,n = 10) and control group(group D,n = 10),continuous inhaling Sachet and Yu-Ping-Feng powder positive control group.group Group B was given Yu-Ping-Feng powder 0.2mg/10g?d-1 orally;Group A,C,and D were given the equal volume of saline(NS) orally;Group A were given Sachet continuous inhalation.Group C discontinuous inhaled.Group E were given Sachet continuous inhalation and Yu-Ping-Feng powder orally.After four weeks mice were stopping taking drugs and were fed on conventional eleven months to observe the effect of Miaoyao anti-influenza sachet on weight and death rate.Results:weight was significantly increased in A,B and E,as compare with C,D(P< 0.05).There is no statistically significant difference between A,B and E(P> 0.05),No significant difference existed between Group C and Group D(P> 0.05).Death rate was significantly decreased in A,B and E,as compare with D(P<0.05).Death rate was decreased in A,B and E,as compare with C(P> 0.05).There is no statistically significant difference between C and D(P>0.05).Conclusion:Miaoyao anti-influenza sachets have protective effect in mice,their protective mechanisms will be further studied.