激光治疗太田痣后色素脱失的发生及影响因素

目的探讨QSNd∶YAG激光和QS红宝石激光治疗太田痣患者后色素脱失的发生情况及其影响因素。方法对266例太田痣患者行激光治疗,长期随访,对收集的患者各项相关临床资料,运用SPSS软件进行统计学分析,并获取患者病变组织进行HE和免疫组化染色观察其组织病理学改变。结果 266例太田痣患者激光治疗后40例发生色素脱失,发生率为15.0%。激光的能量密度、患者首次治疗年龄、太田痣面积以及患者性别与色素脱失的发生相关。免疫组化染色切片显示色素脱失部位黑色素细胞数量较正常皮肤组织无明显改变,但其色素颗粒基本完全消失。结论色素脱失是激光治疗太田痣最常见的并发症之一,激光能量密度、患者首次治疗年龄、太田痣面积等因素影响色素脱失的发生。

A Clinical Study Looking on Hypopigmentation and its Risk Factors in the Laser Treatment of Nevus of Ota

Objective To discuss the Hypopigmentation and its Risk factors of Ota patients treated with QS Nd∶YAG and QS Ruby laser. Methods 266 patients with Ota treated with Q-switched Ruby laser and Q-switched Nd∶YAG laser were followed up and all clinical data were gathered and analyzed by SPSS.A piece of pathology organization was incised and HE staining chemical immunohistochemical staining were adopted. Results 15.0% of the patients appeared hypopigmentation.The fluence of lasers,the first treatment age,the size of the injury and the gender may be risk factors related to hypopigmentation.Chemical immunohistochemical staining showed that melanin granule disappeared in spots of the hypopigmentation. Conclusions Hypopigmentation was one of the most common complication.The fluence of lasers,the first treatment age and the size of the injury which may play important roles in the occurrence of hypopigmentation should be paid more attention during the treatment of Ota.The Ota should be treated as soon as the size of the injury is stable after the diagnosis ensures.