| 小鼠急性重复缺氧后心脏匀浆中出现的一种新物质 |
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| 引用本文： | 王桥,宋学英,刘永利,吕国蔚. 小鼠急性重复缺氧后心脏匀浆中出现的一种新物质[J]. 首都医科大学学报, 2004, 25(1): 7-8 |
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| 作者姓名： | 王桥 宋学英 刘永利 吕国蔚 |
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| 作者单位： | 首都医科大学基础医学院;首都医科大学基础医学院;首都医科大学基础医学院;首都医科大学基础医学院 |
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| 基金项目： | 国家自然科学基金 (3 9670 2 71)，北京市自然科学基金 (7962 0 0 9)资助项目 |
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| 摘 要： | 对小鼠进行急性重复性缺氧 ,并测定未缺氧小鼠及缺氧小鼠心脏匀浆高效液相色谱图。发现小鼠缺氧后 ,心脏匀浆中出现一种新物质 ,且随小鼠缺氧耐受的增加 ,该物质的生成量增大。提示 :该物质是与缺氧密切相关的物质 ,可能是一种能抵抗缺氧、增强耐受的物质抗缺氧因子 ,也可能是机体在抵抗缺氧过程中产生的代谢产物。
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| 关 键 词： | 缺氧症 急性缺氧 高效液相色谱分析 |
| 收稿时间： | 2003-06-29 |
| 修稿时间： | 2003-06-30 |
Change of Heart Homogenate in Mice After Acute Repetitive Hypoxia |
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| Wang Qiao,Song Xueying,Liu Yongli,Lü Guowei School of Basic Sciences,Capital University of Medical Sciences. Change of Heart Homogenate in Mice After Acute Repetitive Hypoxia[J]. Journal of Capital Medical University, 2004, 25(1): 7-8 |
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| Authors: | Wang Qiao Song Xueying Liu Yongli Lü Guowei School of Basic Sciences Capital University of Medical Sciences |
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| Abstract: | The chromatograms of heart homogenate after acute hypoxia in mice were determine d by HPLC. A new compound was found in heart homogenate in mice after hypoxia. A nd the more the tolerant duration increased in mice, the more compounds were pro duced. It was shown the compound was correlative to hypoxia. It may be an antihy poxic factor that can enhance hypoxic tolerance in mice, but it may also be a me tabolite in mice under hypoxia. |
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| Keywords: | anoxia acute hypoxia HPLC |
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