Behavioral responses of high and low active male rats to the chronic ingestion of desipramine |
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Authors: | E L Echandía S T Broitman M R Fóscolo |
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Institution: | Psychiatrische Universitätsklinik, 4025 Basel, Switzerland |
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Abstract: | Male rats arbitrarily selected for high and low motor activity (HA and LA-rats) were submitted to the chronic ingestion (30 days) of desipramine (DSP) in doses of about 1.5, 3 and 6 mg/kg/24 hr. Their motor activity was assessed in an animal activity monitor providing a measure of total horizontal movements and vertical movements and in a hole-board providing a measure of locomotion, head-dipping and grooming. There were significant differences between HA and LA-rats in their behavioral response to DSP treatment. At the doses used DSP did not affect horizontal and vertical movements and hole-board locomotion or exploration in HA-rats (Experiment 1). In LA-rats, however (Experiment 2), these motor activities were significantly stimulated by DSP. Such effect was dose dependent; 1.5 mg/kg/24 hr was ineffective while 6 mg/kg/24 hr produced a clear cut reversion of hypoactivity. It is speculated that DSP treatment increased resistance of LA-rats to the mild stress caused by testing. |
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Keywords: | Chronic methamphetamine Withdrawal Feeding Body weight Circadian rhythmicity Tolerance Glucose-preference-test Medial and lateral hypothalamus |
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