女性冠心病合并2型糖尿病患者的临床和冠脉造影特点

目的:研究女性冠心病(CAD)合并2型糖尿病(DM)患者的临床及冠状动脉造影特点。方法:入选病例为1999-2004 年在我心脏中心住院的240例女性CAD心绞痛患者,根据有无DM分成两组,比较两组的临床特点和冠状动脉造影情况。结果:108个患者(45％)有DM史两组患者在年龄、高血压、血脂异常、吸烟、左主干病变方面比较没有统计学差异(P>0．05), 但DM组绝经患者少于非DM组(P<0．05);DM组的三支血管病变和弥漫性血管病变较多(P<0．05);DM病程对冠状动脉造影所示血管病变无影响(P>0．05);随着空腹血糖水平的升高,三支血管病变和弥漫性病变也增多(P<0．05)。结论:女性 2型DM患者在绝经期前患CAD者多于非DM患者,DM组三支血管病变和弥漫性病变较多。DM病程对冠状动脉造影所示血管病变无影响,但空腹血糖水平的升高促使及加重冠状动脉血管病变。

Features of Clinical and Coronary Angiograph in Female Diabetic Type- 2 Patients with Coronary Atherosclerotic Heart Disease

Objective: To evaluate whether female diabetic with coronary atherosclerotic heart disease differ from nondiabetic in coronary angiography and other clinical data.Methods: Data were prospectively collected in female patients with angina pectoris admitted in our heart centre from 1999 to 2004, 240 female patients were classified into two groups:diabetic and nondiabetic. Results: 108 patients(45%) had a history of diabetes.There was no difference in age,hypertension,smoking, dyslipidemia.More nondiabetic were postmenopausal,on the other hand,diabetic had more triple vessel disease and diffused disease in LAD and LCX than nondiabetic.The duration of diabetes had no effect on results of coronary angiography.But patients with high level of fasting blood glucose had more triple vessel and diffused disease.Conclusion:Compared with female nondiabetic, female diabetic with angina were less postmenopausal and had more triple disease and diffused disease.The duration of diabetes had no effect on results of coronary angiography. Patients with high level of fasting blood glucose were likely to have more triple vessel and diffused disease.