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Clinical pharmacokinetics and pharmacodynamics of fazadinium in renal failure |
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| Authors: | D. R. Bevan J. D. Souza J. M. Rouse J. Caldwell R. L. Smith |
| Affiliation: | (1) Departments of Anaesthesia and Experimental Pharmacology, St. Mary's Hospital Medical School, London, England;(2) Present address: Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada;(3) Department of Anaesthesia, Royal Victoria Hospital, 687 Pine Avenue West, H3A 1A1 Montreal, Quebec, Canada |
| Abstract: | Summary The pharmacokinetic behaviour and neuromuscular blockade produced by the administration of fazadinium bromide at a dose of 1 mg/kg have been studied in seven patients with end-stage renal failure. No significant differences were found in the pharmacokinetic or pharmacodynamic properties when compared with patients with normal renal function. It is suggested that fazadinium may be superior to either d-tubocurarine or pancuronium in providing muscle relaxation for patients with renal failure. |
| Keywords: | neuromuscular relaxants fazadinium pharmacokinetics renal failure neuromuscular transmission |
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