多沙唑嗪对兔食饵性高脂血症作用

目的观察多沙唑嗪(DOX)对动脉粥样硬化兔模型血脂水平的影响。方法健康雄性新西兰兔随机分为普通饮食组、高脂饮食组、DOX治疗组,每组10只。普通饮食组予普通饲料喂养,其余2组予高脂饲料。喂养4周后,DOX治疗组每日定时予DOX1ml/kg腹腔注射,连续给药9周。分别于实验开始时(0周、4周、7周、10周、13周)抽取空腹血标本,检测各组血清总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白胆固醇(LDL-C)。结果高脂饮食组兔血清TC第4周末(28.63±7.65)mmol/L,第13周末(40.83±3.90)mmol/L,血清LDL-C第4周末(16.21±9.59)mmol/L,第13周末(28.46±3.81)mmol/L,随高脂饲养的时间延长,血清TC、LDL-C水平进一步显著升高(P<0.05或<0.01);而DOX治疗组兔血清TC第4周末(29.36±7.94)mmol/L,第13周末(37.59±6.09)mmol/L,血清LDL-C第4周末(17.66±8.84)mmol/L,第13周末(25.50±6.70)mmol/L,血清TC、LDL-C水平未显著升高(P>0.05)。结论 DOX对高血脂兔的血清TC、LDL-C紊乱具有轻度的改善作用。

Effects of doxazosin on blood lipid levels in cholesterol-fed rabbits models

Objective To observe the effect of doxazosin （DOX） on blood lipid levels in rats with atherosclerosis. Methods New Zealand male rabbits were randomly divided into 3 groups：normal diet group, high fat diet group,DOX treatment group,with 10 rabbits in each group. The rabbits in normal diet group were fed with normal feed, however, the rabbits in the latter two groups were fed with high fat diet. After g-week feeding, the rabbits in DOX treatment group were intraperitoneally injected with DOX lmg/kg, once a day for 9 weeks. The serum levels of TC, TG, LDL-C were detected at 0,4,7,10,13 weeks for the three groups. Results The levels of TC in high fat diet group were （28.63±7.65 ） mmol/L at the end of 4 weeks, （40.83 ± 3.90） mmol/L at the end of 13 weeks, and the levels of LDL-C were（ 16.21 ± 9.59）mmol/L at the end of 4 weeks, （28.46 ± 3.81 ）mmol/L at the end of 13 weeks respectively,with the time prolongation of high fat diet feeding,the levels of TC ,LDL-C were increased further （ P 〈0.05 or 〈0.01 ）. However the levels of TC in DOX treatment group were（29.36 ±7.94） mmol/L at the end of 4 weeks, （37.59 ± 6.09）mmol/L at the 13 weeks, and the levels of LDL-C were （17.66 ± 8.84） mmol/L at the end of 4 weeks, （25.50 ± 6.70） mmol/L at the end of 13 weeks, the levels of TC, LDL-C were not increased significantly （ P 〉 0.05 ）. Conclusion DOX can improve the disorder of LDL-C and TC mildly in the rabbits with hyperlipemia.