糖尿病视网膜病变病人血浆VEGF和VWF水平的变化及其临床意义

目的探讨糖尿病视网膜病变（DR）病人血浆血管内皮细胞生长因子（VEGF）和血管性血友病因子（VWF）水平的变化及其临床意义。方法采用ELISA法检测58例DR病人血浆VEGF和VWF的变化，其中，非增生性DR（NPDR）28例，增生性DR（PDR）30例。并与54例非糖尿病视网膜病变（NDR）病人进行比较，同时以49例健康者作为对照。结果糖尿病病人血浆VEGF和VWF明显高于对照组，差异有显著性（t=27．09、28．85，P＜0．001）；DR病人血浆VEGF和VWF明显高于NDR病人，差异有显著性（t=10．35、16．02，P＜0．001）；PDR病人VEGF和VWF明显高于NPDR病人，差异有显著性（t=6．74、7．01，P＜0．001）。NPDR和PDR病人血浆VEGF与VWF呈明显的正相关（r=0．569、0．629，P＜0．001）。结论血浆VEGF和VWF水平变化参与了DR的发生与发展，且与病变程度有关。

CHANGES OF PLASMA VASCULAR ENDOTHELIAL GROWTH FACTOR AND VON WILLEBRAND FACTOR IN PATIENTS WITH DIABETIC RETINOPATHY AND THEIR CLINICAL SIGNIFICANCE

ObjectiveTo explore the changes of plasma vascular endothelial growth factor(VEGF) and von Willebrand factor(VWF) in patients with diabetic retinopathy(DR) and their significance.MethodsBy using ELISA,the changes of plasma VEGF and VWF were detected in 58 DR patients,of whom,non-proliferative DR(NPDR),28 cases;proliferative DR(PDR),30.The results were compare with 54 non-diabetic retinopathy (NDR) patients,and 49 healthy ones served as controls.Results The plasma VEGF and VWF were higher in the diabetic than those in the controls(t=27.09,28.85;P<0.001).The VEGF and VWF were higher in DR patients than those in NDR(t=10.35,16.02;P<0.001).The VEGF and VWF were higher in patients with PDR than those in NPDR(t=6.74,7.01;P<0.001).There were positive correlation between VEGF and VWF in NPDR and PDR(r=0.560,0.629;P<0.001).ConclusionThe changes of VEGF and VWF involve in the occurrence and development of DR,which are responsible for the seriousness of DR.