Ninth International Histocompatibility pre-workshop testing of Dw6 HTCs. Two subtypes of Dw6 |
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| Authors: | A Termijtelen G M Th Schreuder E M Mickelson J J van Rood |
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| Institution: | Department of Immunohaematology and Blood Bank, University Hospital, Leiden, The Netherlands;Puget Sound Blood Center and Fred Hutchinson Cancer Research Center, Seattle, Washington, USA |
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| Abstract: | In the scope of the cellular part of the 9th International Histocompatibility Workshop, the offered homozygous typing cells (HTCs) of several specificities have been screened in a pre-Workshop. In Leiden and Seattle all HTCs typing for "HLA-Dw6" have been tested. This implied that in both laboratories mixed lymphocyte culture (MLC) matrices were performed between the Dw6 HTCs and that all HTCs were tested as stimulator cells against a panel of heterozygous responder cells. The results clearly demonstrated that "HLA-Dw6" as defined by the different participating laboratories can be split into two major groups, Dw6.a and Dw6.b. This observation confirms and extends previous reports. None of the 9th Workshop B-cell sera could discriminate between the two presently described subgroups of HLA-Dw6. |
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