胃肠道间质瘤同时性肝转移的同期手术切除

目的 探讨同时性胃肠道间质瘤(gastrointestinal stromal tumor,GIST)肝转移行同期切除原发肿瘤和肝转移瘤的手术疗效.方法 回顾性分析7例GIST同时性肝转移同期手术病人的临床资料.结果 7例病人中男5例,女2例;中位年龄52(43～67)岁.原发肿瘤部位分布为:胃2例,小肠5例.全组接受手术切除,无明显并发症,1例病人术后2个月死于肝内复发,1例术后8个月肝内复发者服用伊马替尼,肿瘤进展得到控制.其余病人在随访1年期间未见肿瘤复发或转移.结论 同期手术切除对于合适的同时性GIST肝转移瘤病人安全、有效.

Simultaneous resection of gastrointestinal stromal turnout primary neoplasm and synchronous liver metas-tases

Objective To assess the therapeutic effect of simultaneous resection of gastrointesti-nal stromal tumor (GIST) primary neoplasm and synchronous liver metastases. Methods Seven pa-tients who underwent simultaneous resection of GIST primary neoplasm and synchronous liver metas-tases were identified and their clinicopathological data were analyzed retrospectively. Results There were 5 males and 2 females. The median age was 52 years (43-67 years). The distribution of prima-ry neoplasm location included 2 cases in the stomach and 5 in small bowel. All patients received surgi-cal resection without complications. One patient died 2 months after surgery because of recurrent liver disease. One patient received imatinib for remnant recurrent liver disease 8 months after surgery and the disease progression was controlled. Other patients remained alive and well without recurrence or metastases during the follow-up for 1 year. Conclusion Simultaneous resection is safe and effective for selected patients with synchronous GIST liver metastases.