孤立性纤维性肿瘤的临床病理分析

目的探讨孤立性纤维性肿瘤的临床病理特征,诊断及鉴别诊断。方法对1例发生在乳腺的孤立性纤维性肿瘤进行组织学观察和免疫组化检测,并复习相关文献。结果肿瘤由梭形细胞构成,形成细胞稀少区和富于细胞区,两者交替分布,其间有粗大的瘢痕样玻璃变性的胶原纤维,免疫组化bcl-2和CD34阳性表达,CK为阴性。结论孤立性纤维性肿瘤为中间型肿瘤,完整切除后很少复发,但需长期随访。

Clinicopathological Study of Solitary Fibrous Tumor

Objective To study the clinieopathological features,diagnosis and differential diagnosis of solitary fibrous tumor.Methods One case of solitary fibrous tumor in breast was analyzed at light microscopic level and studied by immunohistochemical staining and reviewed the related literatures.Results The tumor was composed of spindle cells,witch arrange sparsely or densely and there are massive and ouloid collagen fiber among the cells.The immunohistochemical result： The cells expressed bcl-2 and CD34,but CK was negative in them.Conclusions solitary fibrous tumor is intermediate type tumor,relatively nonmalignant,and it relapse unfrequently after a complete resection,but this tumor is required long-term follow up.