Association of hypercholesterolemia and apolipoprotein E4 in school children |
| |
| Authors: | Hisako Yanagi Yae Shimakura Yasuko Yamanouchi Yuka Watanabe Shigeru Tsuchiya Hideo Hamaguchi |
| |
| Affiliation: | Department of Human Genetics, University of Tsukuba, Japan. |
| |
| Abstract: | To investigate the association of apolipoprotein (APO) E4 and hypercholesterolemia in children, we studied the APOE phenotypes of 51 school-age children with hypercholesterolemia and of 51 age, sex and obesity index-matched controls with normocholesterolemia by two-dimensional gel electrophoresis APOE4 was present in 21 of 51 hypercholesterolemic children (41.2%), and in nine of 51 control subjects (17.6%). The difference was significant (p less than 0.01). This finding indicates that APOE4 is associated with hypercholesterolemia in children. |
| |
| Keywords: | apolipoprotein E apolipoprotein E polymorphism hypercholesterolemia school children |
|
