组合人工肾与单独血液透析治疗尿毒症疗效的对比研究

目的比较组合人工肾与普通血液透析对尿毒症的治疗效果。方法将28例长期维持血透的患者进入组合人工肾治疗(称治疗组),并与单独血透治疗24例(称对照组)疗效进行对比研究,观察临床症状改善,血尿素氮(blood urea nitrogen,,BUN)、肌酐(creatinine,Cr)、中分子量物质(middle molecular substance,MMS)清除及血常规变化。结果两种方法在清除Bun、Cr方面无明显差异(P>0.05),治疗组在MMS的清除及临床症状的改善方面好于对照组,组间比较有明显差异(P<0.05)。治疗后,组间血常规中白细胞(WBC)、血小板(PLT)计数、血红蛋白含量(Hb)无明显变化(P>0.05)。结论组合人工肾能更好地清除体内中分子物质,明显改善患者临床症状,对血液系统无明显影响。

Contrast Research of Therapeutic Effect on Urinaemia with Component Artificial Kidney and Hematodialysis

Objective To observe the therapeutic effects on urinaemia with component artificial kidney(CAK) and hematodialysis(HD).Methods 28 patients with urinaemia who needed long-term hematodialysis were consid-ered as control group-treated with CAK,another group(n=24) as interfered one-treated with HD alone.The amelio-ration of clinical symptom,clearance rates of urea nitrogen(BUN),creatinine(CR),Middle Molecular Substance(MMS),and variation of blood regular test were all observed.Results Compared with control group,there were no signifi-cant difference to the clearance rates of BUN and CR(P>0.05),but the clearance rate of MMS was higher and the amelioration of clinical symptom was more superior(P<0.05),and there were no obvious difference on variation of white blood cell,hemoglobin and platelet(P>0.05).Conclusion Using CAK could clear up MMS and ameliorate clinical symptom better than using HD alone,with no influence on the function of hematological system.