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p-Chlorophenylalanine-induced alterations in the behavioral effects of 5-hydroxytryptophan |
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| Authors: | W. O. Boggan D. X. Freedman J. B. Appel |
| Affiliation: | (1) Departments of Psychiatry and Psychology, University of Chicago, Chicago, Illinois;(2) Department of Psychology, University of South Carolina, Columbia, South Carolina;(3) Department of Psychiatry and Biochemistry, Medical University of South Carolina, 29401 Charleston, South Carolina, USA |
| Abstract: | Pretreatment of rats with p-chlorophenylalanine methyl ester (PCPA-ME) causes a normally non-effective dose of 5-hydroxytryptophan (5-HTP) to disrupt bar-pressing at times when serotonin (5-HT) concentration is depleted. There does not appear to be any correlation between the initial, behaviorally-distruptive effects of PCPA-ME and the action of this compound on 5-HT biosynthesis. |
| Keywords: | p-Chlorophenylalanine 5-Hydroxytryptophan Serotonin Behavior |
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