| 糖尿病大鼠口服胰岛素油溶液降血糖效果的研究 |
| |
| 引用本文： | 刘蓉,张阳德. 糖尿病大鼠口服胰岛素油溶液降血糖效果的研究[J]. 中国现代医学杂志, 2008, 18(7): 843-846 |
| |
| 作者姓名： | 刘蓉 张阳德 |
| |
| 作者单位： | 1. 卫生部纳米生物技术重点实验室,湖南,长沙,410008
2. 卫生部肝胆肠外科研究中心,湖南,长沙,410008 |
| |
| 摘 要： | 目的评价口服胰岛素油溶液对糖尿病大鼠的降血糖效果。方法将糖尿病大鼠分为3大组：空白组：糖尿病大鼠4只，口服不合胰岛素的油溶液；对照组：糖尿病大鼠4只，经皮下注射2、5IU／kg体重胰岛素水溶液；实验组：口服100、50、25IU／kg体重胰岛素油溶液，每剂量组糖尿病大鼠4只，共12只。每组分别于给药后1．5、3.0和4．5h测定动物血糖。然后对结果进行统计学分析。结果口服胰岛素油溶液能明显降低糖尿病大鼠的血糖，降血糖效果与口服剂量呈正相关趋势，皮下注射胰岛素水溶液的动物血糖在4．5h后出现回升，约为初始值的90％，而口服胰岛素油溶液的动物血糖无回升现象。结论口服胰岛素油溶液能有效降低动物血糖，胰岛素油溶液在口服后有明显的缓释作用。
|
| 关 键 词： | 糖尿病大鼠 血糖 胰岛素油溶液 口服 皮下注射 糖尿病大鼠 口服胰岛素 油溶液 降血糖 效果 研究 diabetes rats solution insulin oral hypoglycemic activity 缓释作用 现象 回升 皮下注射胰岛素 相关趋势 口服剂量 统计学分析 结果 |
| 文章编号： | 1005-8982(2008)07-0843-04 |
| 修稿时间： | 2007-09-10 |
Study on hypoglycemic activity of oral insulin oily solution in rats with diabetes |
| |
| LIU Rong,ZHANG Yang-de. Study on hypoglycemic activity of oral insulin oily solution in rats with diabetes[J]. China Journal of Modern Medicine, 2008, 18(7): 843-846 |
| |
| Authors: | LIU Rong ZHANG Yang-de |
| |
| Affiliation: | LIU Rong1,ZHANG Yang-de2 (1.National Key Laboratory of Nanobiological Technology,Changsha,Hunan 410008,P.R.China,2.National Hepatobiliary , Enteric Surgery Research Center,Ministry of Health,P.R.China) |
| |
| Abstract: | [Objective] To evaluate the hypoglycemic activity of oral insulin oily solution in rats with diabetes. [Methods] Rats with diabetes were divided into 3 groups: 4 diabetic rats took orally negative oily solution without insulin in blank group; 4 diabetic rats were given hypodermic injection of 2.5I U/Kg insulin aqueous solution in control group; In experiment group, 12 diabetic rats were divided into 3 different dosage groups that took 100, 50, 25I U/Kg oral insulin oily solution respectively. The blood gluc... |
| |
| Keywords: | diabetic rats blood glucose oral insulin oily solution oral administration hypodermic injection |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
