福辛普利对糖尿病大鼠肾脏损伤的保护作用

目的探讨福辛普利对糖尿病大鼠肾脏损伤的保护机制。方法制备大鼠糖尿病模型并分别给予不同剂量福辛普利灌胃。12周后检测血糖、血清肌酐、肾重指数，观察肾小球体积、肾小球基底膜变化，测定肾小球平均截面积（MGA）和肾小球平均体积（MGV）。结果DM组及不同剂量福辛普利组间血糖、血清肌酐均无统计学差异；与DM组相比，5mg·kg^-1·d^-1组肾重指数降低（P〈0．05），10mg·kg^-1·d^-1组肾重指数明显降低（P〈0．01），各福辛普利组MGA和MGV均缩小（P均〈0．01）。结论早期应用福辛普利在一定程度上可减轻糖尿病大鼠肾脏的损伤。

Protective effect of fusinopril on renal damage in rats with diabetics mellitns

Objective To investigate the protective effects of fosinopril on the diabetic nephropathy in diabetic rats. Methods Diabetic model rats were established by intra-abdominal injection of streptozotocin. Fosinopril-treated rats were administered by gastric canal at different dose of fosinopril respectively. Affer 12 weeks, blood sugar and creatinine, kidney weight index were examined in all groups. Kidney paraffin section was prepared. Glomerular volume, basement membrane changes, mean glornerular section area （MGA） and volume （MGV） were determined. Results The blood suger and creatinine did not change obviously. Kidney weight index had no significant differences in 2.5mg·kg^-1·d^-1 group,but had significant differences in 5mg·kg^-1·d^-1 group（P〈0.05）and 10mgmg·kg^-1·d^-1 group（P 〈0. 01）. MGA and MGV in fosinopril-treated groups had significant diminutions as compared with DM group（P〈0. 01）. Conclusions Fosinopril administered in early stage could attenuate the kidney damage in diabetic rats.