血清透明质酸和层粘连蛋白检测在肝纤维化诊断中的价值

目的　探讨血清中透明质酸（ Ｈ Ａ） 和层粘连蛋白（ Ｌ Ｎ） 含量的变化在肝纤维化诊断中的意义。方法　应用放射免疫分析技术，对１２０ 例各种肝病患者及５０ 例正常对照者血清中 Ｈ Ａ 和 Ｌ Ｎ 进行联合检测。结果　各肝病组患者血清中 Ｈ Ａ 和 Ｌ Ｎ 含量均高于正常对照组，尤以肝硬化和慢性活动性肝炎患者最为显著， Ｈ Ａ 和 Ｌ Ｎ 的变化与肝病的病变程度和肝纤维化活动度呈密切正相关，同时测定 Ｈ Ａ 和 Ｌ Ｎ 可显著提高阳性诊断率。结论　血清 Ｈ Ａ 和 Ｌ Ｎ 的检测是反映肝病发展及肝纤维化程度，是鉴别有关肝病敏感且可靠的诊断指标。

VALUE OF DETERMINATION OF BOTH HYALURONIC ACID AND LAMININ IN SERUM IN DIAGNOSING HEPATIC FIBROSIS

Objective To explore the significance of variations of Hyaluronic acid (HA) and Laminin(LN) contents in serum in diagnosing hepatic fibrosis.Methods Both HA and LN in serum were jointly determined by radioimmunoassay in 120 cases of various hepatic diseases and 50 cases in normal control group.Results The levels of HA and LN in serum of patients with hepatic disease group were higher than those of the control group,especially for those patients with liver cirrhosis(LC) and chronically active hepatitis(CAH).The concentrations of HA and LN were positively correlated with the degrees of pathological changes of hepatic disease and the activity of hepatic fibrosis.Simultaneously determination of both HA and LN can obviously increase the rate of positive diagnosis.Conclusion The determination of HA and LN in serum is a sensitive and reliable diagnostic method in reflecting the degrees of hepatic disease development and hepatic fibrosis and identifying relevant hepatic diseases.