Interstitial deletion of the long arm of chromosome 11 determined by fluorescencein situ hybridization |
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| Authors: | Tada-aki Hori Mitsuo Masuno Akihiro Wakazono Ei-ichi Takahashi Reiko Katakura Tadao Orii |
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| Affiliation: | (1) Division of Genetics, National Institute of Radiological Sciences, Anagawa, Inage-ku, 263 Chiba, Japan;(2) Department of Pediatrics, Gifu University, School of Medicine, Tsukasa-machi, 500 Gifu, Japan;(3) Division of Pediatrics, Hashima Municipal Hospital, Shinsei-cho, 501-62 Hashima, Japan;(4) Present address: Division of Medical Genetics, Kanagawa Children's Medical Center, Mutsukawa, Minami-ku, 232 Yokohama, Japan |
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| Abstract: | Summary An interstitial deletion, del(11)(q14q22), found in a female infant was examined by fluorescencein situ hybridization with cosmid DNA markers mapped on the long arm of chromosome 11. Three cosmids mapped on 11q14.1-11q22.1 region were not hybridized to the del(11) chromosome, while all the other DNA markers mapped on 11cen-11q14.1 and 11q23.1-11 qter region gave hybridization signals on the del(11) chromosome. Cytogenetic analysis after R-banding confirmed an apparent deletion of 11q14-q22, but containing a small R-negative band, a part of 11q22.3 and/or 11q14.1, in the middle part of del(11) chromosome. The karyotype thus was determined to be 46, XX, del(11)(q14.1q22.3). |
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| Keywords: | interstitial deletion del(11)(q14q22) fluorescencein situ hybridization cosmid clones |
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