高血黏度大鼠血液有形成份及血液流变性的动态观察

目的检测高分子右旋糖酐法致高血黏度大鼠模型血液有形成份及血液流变性指标,寻找其变化规律并分析原因。方法将大鼠随机分为高血黏度模型组和空白对照组,连续检测模型组动物10日内全血黏度、血浆黏度、血沉、血浆纤维蛋白原及血液有形成份的变化。结果与对照组比较,模型组大鼠白细胞、红细胞、红细胞比容、血红蛋白和血小板逐渐减少-全血黏度升高-血浆纤维蛋白原和血浆黏度呈正相关增高趋势-血沉增快非常明显,5d后保持在极快水平。结论高分子右旋糖酐可引起全血黏度及血浆黏度升高,红细胞破坏,红细胞比容和血红蛋白含量降低,白细胞和血小板附壁,红细胞聚集性增强。

The Experimental Study on Blood Components and Hemorheology in High Blood Viscosity Rats

Objective To detect indexes of the visible components and hemorheology of high blood vi- scosity rats model by high polymer dextran, look for the law of changes and analyze causes. Methods Rats were randomly divided into high blood viscosity group and the normal control group. Whole blood viscosity, plasma viscosity, erythrocyte sedimentation, fibrinogen and visible components were determined continuously in 10 days and compared with the normal control group. Results Leucocyte, erythrocyte, hematocrit, ferrohemoglobin and platelet reduced obviously. Whole blood viscosity increased. The contents of fibrinogen and plasma viscosty increased obviously and they were proportional. Er ythrocyte sedimentation changed very fast and was keeping fast level after five days. Conclusions High polymer dextran can increase whole blood viscosty and plasma viscosity. High polymer dextran can damage erythrocyte, this cause hematocrit and ferrohemoglobin to reduce. Leucocyte and platelet rely on endothelium of blood vessel. The aggregation of erythrocyte increased.