| 胍丁胺对实验性变态反应性脑脊髓炎中枢神经系统内细胞因子IFN-γ、IL-10的影响 |
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| 引用本文： | 潘大津,郑荣远. 胍丁胺对实验性变态反应性脑脊髓炎中枢神经系统内细胞因子IFN-γ、IL-10的影响[J]. 中国临床药理学与治疗学, 2008, 13(11) |
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| 作者姓名： | 潘大津 郑荣远 |
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| 作者单位： | 1. 浙江省丽水市第二医院老年病科,丽水323000,浙江
2. 温州医学院附属第一医院神经内科,温州325000,浙江 |
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| 摘 要： | 目的:观察胍丁胺对实验性变态反应性脑脊髓炎(EAE)中枢神经系统(CNS)内细胞因子IFN-γ和IL-10的影响。方法:用豚鼠全脊髓匀浆免疫Wistar大鼠建立EAE动物模型,应用双抗体夹心ELISA法观察不同剂量胍丁胺(分别为25、50、100 mg/kg)对EAE大鼠脑和脊髓组织内细胞因子IFN-γ和IL-10水平的影响。结果:胍丁胺可降低Wistar大鼠EAE的发病率,减轻其临床症状。与空白对照组比较,模型组大鼠脑和脊髓组织中的IFN-γ水平增加和IL-10水平降低(P<0.05或P<0.01),而胍丁胺干预的3组大鼠CNS内脑和脊髓组织中的IFN-γ水平降低和IL-10水平增加。结论:胍丁胺能调节EAE中的Th1/Th2比例平衡,降低IFN-γ水平,升高IL-10水平。
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| 关 键 词： | 实验性变态反应性脑脊髓炎 胍丁胺 γ-干扰素 白介素-10 |
Effects of agmatine on the levels of IFN-γ, and IL-10 of the central nervous system in experimental allergic encephalomyelitis |
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| PAN Da-jin,ZHENG Rong-yuan. Effects of agmatine on the levels of IFN-γ, and IL-10 of the central nervous system in experimental allergic encephalomyelitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(11) |
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| Authors: | PAN Da-jin ZHENG Rong-yuan |
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| Affiliation: | PAN Da-jin1; ZHENG Rong-yuan2 1Second People s Hospital of Lishui City; Lishui 323000; Zhejiang; China; 2First Affiliated Hospital of Wenzhou Medical College; Wenzhou 325000; |
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| Abstract: | AIM: To observe the effects of agmatine(AGM) on the levels of IFN-γ and IL-10 of the central nervous system(CNS) in experimental allergic encephalomyelitis(EAE).METHODS: EAE was induced in Wistar rats by immunization of spinal cords homogenate of guinea pigs(GPSCH) and completed Freund s adjuvant(CFA).EAE rats received AGM intraperitoneally at 25 mg/kg,50 mg/kg,100 mg/kg per day for two weeks,respectively,the levels of IFN-γ and IL-10 of the CNS in EAE were observed with the method of sandwich-enzyme-linked... |
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| Keywords: | experimental allergic encephalomyelitis agmatine IFN-γ IL-10 |
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