| 巯基乙酸的经皮毒性及诱变性研究 |
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| 引用本文： | 宋春华 甘卉芳. 巯基乙酸的经皮毒性及诱变性研究[J]. 工业卫生与职业病, 1990, 16(3): 145-148 |
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| 作者姓名： | 宋春华 甘卉芳 |
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| 作者单位： | 哈尔滨医科大学公共卫生学院，哈尔滨医科大学公共卫生学院 哈尔滨市大直街41号，150001，哈尔滨市大直街41号，150001 |
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| 摘 要： | 本文从急性毒性、亚慢性毒性和诱变性三个方面探讨了巯基乙酸的经皮毒效应。其大、小鼠经皮LD_(50)分别为926mg/kg和1210mg/kg;大鼠90天经皮染毒,试验组BUN含量高于对照组,光镜下,试验组睾丸的组织学结构有明显改变;枯草杆菌DNA重组试验、小鼠骨髓多染红细胞微核试验和小鼠睾丸染色体畸变分析试验均获得阳性结果。
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| 关 键 词： | 巯基乙酸 经皮毒性 诱变性 |
A STUDY ON TOXICITY AND MUTAGENICITY OF THIOGLYCOLLIC ACID THROUGH PERCUTANEOUS ADMINISTRATION |
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| Song Cunhua Gan Huifang. A STUDY ON TOXICITY AND MUTAGENICITY OF THIOGLYCOLLIC ACID THROUGH PERCUTANEOUS ADMINISTRATION[J]. Industrial Health and Occupational Diseases, 1990, 16(3): 145-148 |
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| Authors: | Song Cunhua Gan Huifang |
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| Abstract: | The acute and subacute toxicity and mutagenicity of thioglycoll acid were determined through percutaneous administration. The endermic LD50 to rat and mouse were 926 mg/Kg and 1210 mg/Kg respectively. The results of subscute toxicity test in rats showed that the content of blood urea nitrogen (BUN) in exposure groups was higher than that in control group, the histopathological changes of testis observed in exposure groups were obvious. Mutagenic tests including bacillus subtilis DNA rec-assay, micronucleus test and testes chromosome aberration analysis all showed positive results. |
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| Keywords: | thioglycollic acid percutaneous toxicity mutagenicity |
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