An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media |
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| Authors: | Stanojević Marija Krusić Melina Kalagasidis Filipović Jovanka Parojcić Jelena Stupar Mirjana |
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| Affiliation: | a Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Serbia, Montenegrob Department of Organic Chemical Technology, Faculty of Technology and Metallurgy, University of Belgrade, Serbia, Montenegro |
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| Abstract: | The hydrogels prepared by free radical copolymerization of acrylamide and itaconic acid were investigated with regard to their composition and crosslinking degree to find materials with satisfactory swelling and drug release properties. Samples were characterized by measuring the swelling behavior and in vitro release of paracetamol as a model drug in aqueous media with different pH values. The two-factor, three-level experimental design and response surface methodology were applied to statistically evaluate the influence of investigated factors. |
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| Keywords: | Experimental Design Hydrogels Paracetamol Release Swelling |
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