| 甲氧滴滴涕对雌性大鼠性腺毒性作用及其机制研究 |
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| 引用本文： | 常飞,汪惠文,陈必良,马向东.甲氧滴滴涕对雌性大鼠性腺毒性作用及其机制研究[J].重庆医学,2011,40(1):9-11. |
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| 作者姓名： | 常飞 汪惠文 陈必良 马向东 |
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| 作者单位： | 兰州军区总医院妇产科;兰州军区总医院麻醉科;第四军医大学附属西京医院妇产科; |
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| 摘 要： | 目的 探讨甲氧滴滴涕(MXC)对雌性大鼠性腺毒性的作用机制.方法 成年雌性清洁级SD大鼠40只,按体质量随机分成4组,染毒剂量分别为0、16、32、64 mg/kg.每天以1 mL/100 g体质量腹腔注射染毒,连续20 d.结果 高、中剂量染毒组大鼠动情周期延长,与对照组比较差异有统计学意义(P＜0.05).各染毒组...
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| 关 键 词： | 甲氧氯 受体 雌激素 性腺毒性 |
Research of relation between female gonad toxicity of methoxychlor on rats and the expression of estrogen receptor in uterus and ovary |
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| Chang Fei,Wang Huiwen,Chen Biliang,Ma Xiangdong.Research of relation between female gonad toxicity of methoxychlor on rats and the expression of estrogen receptor in uterus and ovary[J].Chongqing Medical Journal,2011,40(1):9-11. |
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| Authors: | Chang Fei Wang Huiwen Chen Biliang Ma Xiangdong |
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| Institution: | Chang Fei1,Wang Huiwen2,Chen Biliang3,Ma Xiangdong3(1.Department of Obstetrics and Gynecology,2.Department of Anesthesiology,the General Hospital of Lanzhou Military Command,Gansu 730050,China,3.Department of Obstetrics and Gynecology,Xijing Hospital,Fourth Military Medical University,Shanxi 710033,China) |
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| Abstract: | Objective To study the relation between female gonad toxicity of methoxychlor on rats and the expression of estrogen receptor(ER) in uterus and ovary.Metheds 40 SD female rats were randomly divided into 4 groups base on body weight and were injected subcutaneously by the 4 dose levels(o,16,32,64 mg/kg body weight) for 20 days.Vaginal smears of rats were taken to determine estrous cycle.The rats were sacrificed on the day of estrus stage.Body weights,estrus stage,organ weights and organ coefficients of ovary... |
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| Keywords: | methoxychlor receptors estrogen gonad toxicity |
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