靶向葡萄糖代谢以外营养物质的纳米药物在肿瘤饥饿治疗中的应用

饥饿治疗是一种新兴的肿瘤治疗手段，其靶向肿瘤细胞异常活跃的营养物质吸收和代谢途径，抑制和杀伤肿瘤。除了葡萄糖以外，饥饿治疗的靶点也包括肿瘤细胞内的其他营养物质。然而，靶向效率较差以及药物耐受等问题可能会影响其临床转化。近年来，纳米材料辅助的饥饿治疗快速发展，可以部分解决上述问题。本文介绍了一系列具有饥饿治疗作用以及将饥饿治疗与其他疗法相结合的纳米药物，其靶向葡萄糖代谢以外的营养物质，包括乳酸、氨基酸和脂质，为进一步开发具有饥饿治疗作用的纳米药物提供参考。

Application of nanomedicines targeting non-glucose nutrients in tumor starvation therapy

Starvation therapy is an emerging oncological treatment that targets the abnormally elevated nutrient uptake and metabolic pathways to inhibit and kill tumors. In addition to glucose, the targets of starvation therapy also include other nutrients in tumor cells.However, concerns like ineffective targeting and drug tolerance probably have an impact on their clinical translation.Nanomaterial-assisted starvation treatment has been developing quickly in recent years to address these concerns.In this review, several exemplary nanomedicines for starvation therapy and combined starvation therapy with other therapies were offered.They target nutrients other than glucose metabolism, including lactic acid, amino acids, and lipids, using nanomaterials to improve the efficacy of starvation therapy.This review provides reference for further development of nanomedicines with starvation treatment effect.