帕金森病患者血清胰岛素样生长因子-Ⅰ与一氧化氮水平的变化

目的探讨血清一氧化氮（NO）、生长激素（GH）、胰岛素样生长因子-Ⅰ（IGF-Ⅰ）及胰岛素样生长因子结合蛋白-3（IGFBP-3）在帕金森病（PD）患者中的改变特征。方法采用硝酸还原酶法和化学发光法分别检测80例PD患者和78例健康体检者血清NO、GH、IGF-Ⅰ和IGFBP-3水平,并对两组结果进行对比分析。结果 PD组血清NO水平低于对照组（[3.3±0.4）（5.2±0.4）mol/L,〈0.01];PD组的血清IGF-Ⅰ浓度高于对照组（[166±43）（136±35）ng/mL,〈0.01],但两组血清GH和IGFBP-3水平比较差异无统计学意义（〉0.05）。结论 PD患者的血清NO水平降低,IGF-Ⅰ水平上升,这可能与PD时机体对潜在的病理紊乱产生的局部适应反应和保护机制有关。

Changes of serum nitric oxide and insulin-like growth fector-1 levels in Parkinson's disease

Objective To investigate the role of serum nitric oxide （NO）,growth hormone （GH）,insulin-like growth fector-1 （IGF-1） and insulin-like growth binding protein-3（IGFBP-3） concentrations in the patients with Parkinson＇ s disease （PD）. Methods 80 patients with PD and 78 matched healthy subjects as controls were included in this study. The serum NO were measured by nitrate reductase technique and GH,IGF-1 and IGFBP-3 were detected by Chemiluminescence detection. Results The serum NO level of patients in PD group was sig-nificantly lower than that of the control group （[3.3±0.4）vs（5.2±0.4） mol/L,P0.01]. The serum IGF-1 in PD group was higher than that of the control group（[166±43）vs（136±35）ng/mL,P0.01]; however,there were no statistically significant differences on the GH,IGFBP-3 levels between the two groups （P0.05）. Conclusions The decreased NO level and the elevated concentration of IGF-Ⅰ in the serum of patients with PD may be associated with adaptation or protective mechanisms in the neurodegerative disease processes such as PD.