慢性阻塞性肺疾病急性加重期血清IL-8水平检测及临床意义

目的探讨白细胞介素-8(IL-8)与慢性阻塞性肺疾病(COPD)的关系及其作为判断预后的作用。方法采用放射免疫分析法,对45例COPD急性发作期患者治疗前及10～14d病情缓解后分别测定外周血清的IL-8水平,并与10例正常对照者相比较。结果COPD急性发作时外周血清IL-8明显高于缓解后水平(P<0.01),且非存活组患者外周血IL-8水平显著高于存活组(P<0.01)。结论IL-8参与COPD的气道炎症反应。高水平的血清IL-8提示预后不良。

Significance of detecting IL -8 in peripheral blood during acute episodes in patients with chronic obstructive pulmonary disease

Objective To study whether Interleukin-8 was involved in chronic obstructive pulmonary disease(COPD). Methods Serum IL-8 levels of 45 cases of acute exacerbations and in the stable period with treatment for 10~14 days were assaied by RIA,and compared with 10 normal controls.Results The levels of IL-8 in cases during exacerbation were significantly higher than those in stable period (P<0.01),and the level of serum IL-8 was significantly higher in the non-survivors than in the survivors among these cases ( P< 0.01).Conclusion These findings indicated that IL-8 was involved in the airway inflammatory reaction of chronic obstructive pulmonary diseases. High levels of serum IL-8 could predict a poor prognosis for them.