Mouse mammary tumor virus and mammary tumorigenesis in wild mice |
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| Authors: | Shunsuke Imal |
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| Institution: | Nara Pretecturel Institute of Public Health, Nara, Japan |
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| Abstract: | The current knowledge of the distribution of the mouse mammary tumor virus (MMTV) proviral genomes and the mechanism of mammary tumorigenesis by MMTV in mice, with the main emphasis on Asian feral mice, is reviewed. The relevant earlier discoveries on the mode of MMTV transmission are summarized to provide an outline of the biology of MMTV. Finally, the viral etiology of human breast cancer will be discussed. |
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| Keywords: | animal models breast cancer mammary tumorigenesis mouse mammary tumor virus |
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