| 鼻咽癌病变过程中DNA依赖蛋白激酶表达水平的相关研究 |
| |
| 引用本文： | 周小军,王书芹,王士贞,阮岩,禤瑞霞,刘蓬,邱宝珊.鼻咽癌病变过程中DNA依赖蛋白激酶表达水平的相关研究[J].国外医学：内科学分册,2007,34(9):507-508,513,F0003. |
| |
| 作者姓名： | 周小军 王书芹 王士贞 阮岩 禤瑞霞 刘蓬 邱宝珊 |
| |
| 作者单位： | 广州中医药大学中山附属医院 广东中山528400(周小军，王书芹，禤瑞霞)，广州中医药大学附属第一医院 广东广州510405(王士贞，阮岩，刘蓬，邱宝珊) |
| |
| 摘 要： | 目的研究鼻咽癌病变过程中DNA依赖蛋白激酶(DNA-PKcs)表达规律。方法在鼻咽癌高发区,选择鼻咽炎患者30例、鼻咽上皮细胞不典型增生或化生患者42例及鼻咽癌患者34例作为研究对象,免疫组化检测患者鼻咽组织DNA-PKcs的表达水平。结果鼻咽炎、鼻咽上皮细胞不典型增生或化生及鼻咽癌患者鼻咽组织DNA-PKcs的表达水平分别是6.7%、64.3%、55.9%(P<0.001),依据病理分级严重程度的不同,DNA-PKcs呈现不同的表达水平。结论DNA-PKcs在鼻咽癌变过程中可能发挥一定的作用。
|
| 关 键 词： | 鼻咽炎 鼻咽癌前病变 鼻咽癌 DNA依赖蛋白激酶 临床研究 |
| 文章编号： | 1004-2369（2007）09-0507-02 |
| 修稿时间： | 2007-03-142007-05-15 |
Expression of DNA-dependent protein kinase in the nasopharyngeal tissue during carcinogenesis |
| |
| ZHOU Xiao-jun,WANG Shu-qin,WANG Shi-zhen,RUAN Yan,XUAN Rui-xia,LIU Peng,QIU Bao-shan.Expression of DNA-dependent protein kinase in the nasopharyngeal tissue during carcinogenesis[J].Foreign Medical Sciences(Section of Internal Medicine),2007,34(9):507-508,513,F0003. |
| |
| Authors: | ZHOU Xiao-jun WANG Shu-qin WANG Shi-zhen RUAN Yan XUAN Rui-xia LIU Peng QIU Bao-shan |
| |
| Institution: | 1.Department of Otorhinolaryngology, The Zhongshan Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Zhongshan 528400, China ; 2 Department of Otorhinolaryngology, The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China |
| |
| Abstract: | Objective To observe the expression of DNA-dependent protein kinase(DNA-PKcs)in the nasopharyngeal tissue during carcinogenesis.Methods Patients including 30 cases of nasopharyngitis,42 cases of nasopharyngeal precancerous lesion and 34 cases of nasopharyngeal carcinoma(NPC)were chosen from Zhongshan area in which there is high incidence rate of NPC.The expression of DNA-PKcs in the nasopharyngeal tissue was examined by immunohistochemistry.Results The expression rate of DNA-PKcs in the nasopharyngitis tissue,the nasopharyngeal precancerous lesion and the NPC was 6.7%,64.3% and 55.9% respectively(P<0.001).Conclusion The expression of DNA-dependent protein kinase may play an important role in nasopharyngeal tissue carcinogenesis. |
| |
| Keywords: | Nasopharyngitis Nasopharyngeal precancerous lesion Nasopharyngeal carcinoma DNA-dependent protein kinase(DNA-PKcs) Clinical study |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
