多发性硬化与乙肝病毒感染

应用ELISA法,配对检测46例(确诊和拟诊各23例)多发性硬化(MS),43例其它神经科疾病(其它组)和34例非神经科病对照组的血清和CSF的HBsAg,抗—HBs,HBeAg,抗—HBe和抗—ABc。结果为:(1)血清中有HBV感染者:确诊MS组18例(78％),可疑MS组13例(56％),其它组13例(30％),对照组16例(47％)。(2)各组血清中仅含有抗—HBs和/或抗—HBe阳性者在确诊MS组的阳性率与其它组及对照组有极显著性差异(P<0.01)。本研究提示:MS血清中HBV感染显著增高。

Multiple sclerosis and hepatitis B virus infection.

Paired serum and cerebrospinal fluid (CSF) from 46 patients with multiple sclerosis (MS) (definite and probably 23 respectvely),43 with other neurological diseases (OND) and 34 with nonneurological diseases (control) were analysed for the presences of HBsAg,anti-HBs,HBeAg,anti-HBe and anti-HBc by a specific enzyme-linked immunabsobent assay (ELISA).All the 123 patients had not been vaccinated with hepatitis B virus vaccin.The HBV infectious rate (78%) is significantly higher in the definite MS groups than in OND (30%) (p<0.01) and the control (47%) (p<0.05),respectively.The HBV infectious rate in the probable MS group (56%) is also significantly higher than that in OND.It was also found that the positive rates of HBsAg,HBeAg and /or anti-HBc did not show a signifi-cant difference among the four group.But the positive rates of an-ti-HBs and /or anti-HBe in sera from definite MS were significantly higher than those in OND and control.It was suggested that HBV infection may be associated with MS in the pathogenesis.