| 银杏内酯B注射液Beagle犬药代动力学研究 |
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| 引用本文： | 张现涛,焦豪妍,索其良. 银杏内酯B注射液Beagle犬药代动力学研究[J]. 中药材, 2012, 0(5): 762-765 |
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| 作者姓名： | 张现涛 焦豪妍 索其良 |
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| 作者单位： | 广东省中药研究所创新药物研究中心 |
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| 基金项目： | 国家自然科学基金(81001384);广东省科技计划项目(2010B030700020) |
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| 摘 要： | 目的:研究Beagle犬静脉滴注银杏内酯B注射液后的药代动力学特征。方法:采用LC-MS法测定银杏内酯B经时血药浓度,采用DAS 2.0实用药代动力学程序计算其药代动力学参数。结果:Beagle犬单次静脉滴注低、中、高三个剂量银杏内酯B注射液,银杏内酯B主要药代动力学参数:Tmax分别为0.444、1、1 h,Cmax均值分别为0.764、3.024、11.013 mg/L,AUC0-t均值分别为1.007、3.644、16.646 mg.h/L。结论:各剂量组血药浓度试验数据经拟和优度分析,药物消除符合二室模型,AUC0-t、AUC0-∞、Cmax随剂量的增加而增加,均呈剂量依赖性的正比关系,体内动力学过程符合线性动力学特征。
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| 关 键 词： | 银杏内酯B注射液 血药浓度 药代动力学 LC-MS Beagle犬 |
Study on Pharmacokinetics of Ginkgolide B Injection in Beagle Dogs |
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| ZHANG Xian-tao,JIAO Hao-yan,SUO Qi-liang. Study on Pharmacokinetics of Ginkgolide B Injection in Beagle Dogs[J]. Journal of Chinese medicinal materials, 2012, 0(5): 762-765 |
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| Authors: | ZHANG Xian-tao JIAO Hao-yan SUO Qi-liang |
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| Affiliation: | (Guangdong Research Institute of Traditional Chinese Medicine,Guangzhou 510520 China) |
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| Abstract: | Objective:To study the pharmacokinetics of ginkgolide B injection in Beagle dogs.Methods:Determined the serum concentration of ginkgolide B by LC-MS and calculated its parameter of pharmacokinetics via DAS 2.0 software.Results:After intravenous drips of 0.62,2.07 and 10.35 mg/kg ginkgolide B,parameters of pharmacokinetics of ginkgolide B were as follows:Tmax were 0.444,1,1 h;Cmax were 0.764,3.024,11.013 mg/L;AUC0-t were 1.007,3.644,16.646 mg·h /L.Conclusion:Ginkgolide B has two compartment model in Beagle dogs. |
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| Keywords: | Ginkgolide B injection Plasma drug concentration Pharmacokinetics LC-MS Beagle dogs |
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