抗焦虑对胃癌根治术患者七氟烷用量及术后恢复的影响

目的:研究劳拉西泮联合咪达唑仑对择期胃癌根治术患者抗焦虑作用的有效性,及该方法对术中七氟烷用量和术后疼痛的影响.方法:观察组手术前1d服劳拉西泮,术前40min静注咪达唑仑,术中BIS监测控制麻醉深度,观察两组患者术前Spielberge状态—特质焦虑问卷(STAI)评分,术中七氟烷用量,麻醉恢复时间及术后2、6、24h疼痛VAS评分.结果:观察组状态-特质焦虑问卷评分低于对照组(S-AI:53.60±4.45vs62.70±3.98,P<0.05;T-AI:54.78±3.97vs65.65±4.21,P<0.05),七氟烷的使用量少于对照组(34.70±0.46vs36.20±0.44,P<0.05).两组术后苏醒及拔管时间无统计学差异.两组患者术后6、24hVAS评分,观察组低于对照组(6hVAS评分:3.45±1.60vs4.89±1.91,P<0.05;24hVAS评分:3.51±1.76vs5.17±1.71,P<0.05).结论:劳拉西泮联合咪达唑可以减轻术前患者的焦虑状态,减少术中七氟烷的使用,有利于减轻患者术后疼痛.

Effect of anti-anxiety treatment on sevoflurane requirement and postoperative recovery in patients undergoing radical gastrectomy

AIM: To investigate the effect of anti-anxiety treatment with lorazepam and midazolam on sevoflurane requirement and postoperative recovery in patients undergoing radical gastrectomy. METHODS: Sixty patients undergoing radical gastrectomy were divided into two groups: observation group and control group. The observation group was administered with lorazepam the night before surgery and midazolam 40 min before the induction of anesthesia, while the control group was not given such drugs. BIS monitoring was used to control the depth of anesthesia. The Spielberger State-Trait Anxiety Inventory (STAI) scores were obtained preoperatively, while the requirement of sevoflurane during operation and the VAS scores 2 h, 6 h and 24 h postoperatively were also calculated. RESULTS: The observation group had lower STAI scores (S-AI: 53.6 ± 4.45 vs 62.70 ± 3.98, P < 0.05;T-AI: 54.78 ± 3.97 vs 65.65 ± 4.21, P < 0.05) and less requirement of sevoflurane during operation (34.7 ± 0.46 vs 36.2 ± 0.44, P < 0.05). The VAS scores at 6 and 24 hours postoperatively were lower in the observation group (6 h: 3.45 ± 1.60 vs 4.89 ± 1.91, P < 0.05; 24 h: 3.51 ± 1.76 vs 5.17 ± 1.71, P < 0.05) than in the control group. There were no significant differences in awaking time and extubation time between the two groups (both P > 0.05). CONCLUSION: Combined use of lorazepam and midazolam can reduce preoperative anxiety, intraoperative sevoflurane requirement, and postoperative pain in patients undergoing radical gastrectomy.