| 石墨烯-Nafion-纳米金增敏印刷电极伏安法测定青藤碱 |
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| 引用本文： | 杨欣,陈迪钊,林红卫,袁吉,李龙飞. 石墨烯-Nafion-纳米金增敏印刷电极伏安法测定青藤碱[J]. 药物分析杂志, 2012, 0(8): 1435-1439,1430 |
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| 作者姓名： | 杨欣 陈迪钊 林红卫 袁吉 李龙飞 |
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| 作者单位： | 怀化学院化学与化学工程系;民族药用植物资源研究与利用湖南省重点实验室 |
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| 基金项目： | 怀化学院大学生研究性学习和创新性实验项目(2011-16);湖南省高校“中药制剂工程与质量控制”产学研合作示范基地建设项目;怀化学院校级科研课题(HHUY2011-08);湖南省自然科学基金(11JJ6011) |
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| 摘 要： | 目的:采用石墨烯(GS)-Nafion-纳米金(Au)增敏印刷电极(SPCEs)建立青藤碱(SN)的测定方法,探讨SN在修饰电极上的电化学行为。方法:将GS-Nafion溶液涂覆于SPCEs表面制得GS-Nafion︱SPCEs电极,然后于上述电极表面化学镀Au制得Au/GS-Nafion︱SPCEs电极,在B-R缓冲液中,采用循环伏安(CV)和示差脉冲伏安(DPV)法研究SN的电化学性质。结果:在优化的实验条件下,DPV氧化峰电流与SN浓度在5.0×10-7～1.0×10-4mol.L-1范围内呈良好的线性关系,检出限为2.2×10-7mol.L-1。结论:该修饰电极价格低廉,制备容易,样品用量少,抗干扰性强,可用于正清风痛宁注射液中SN含量测定。
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| 关 键 词： | 青藤碱电化学性质 石墨烯 纳米金 印刷电极 循环伏安法(CV) 示差脉冲伏安法(DPV) |
Determination of sinomenine by graphene sheetNafion-gold nanopartical-sensitized screen-printed carbon electrodes for voltammeter |
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| YANG Xin,CHEN Di-zhao,LIN Hong-wei,YUAN Ji,LI Long-fei. Determination of sinomenine by graphene sheetNafion-gold nanopartical-sensitized screen-printed carbon electrodes for voltammeter[J]. Chinese Journal of Pharmaceutical Analysis, 2012, 0(8): 1435-1439,1430 |
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| Authors: | YANG Xin CHEN Di-zhao LIN Hong-wei YUAN Ji LI Long-fei |
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| Affiliation: | 1(1.Department of Chemistry and Chemical Engineering,Huaihua College,Huaihua 418000,China; 2.Hunan Province Key Laboratory for Research and Utilization of Ethnomedicinal Plant Resources,Huaihua 418000,China) |
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| Abstract: | Objective:To investigate the electrochemical behavior of sinomenine(SN) by screen-printed carbon electrodes(SPCEs) sensitized by graphene sheets(GS),Nafion and gold nanoparticals(Au).Methods:SPCEs was coated by GS-Nafion solution and Au was painted on its surface to fabricate Au/GS-Nafion︱SPCEs electrode.The electrochemical characteristics of SN were studied by cyclic voltammetry(CV) and differential pulse voltammetry(DPV) in a Britton-Robinson(B-R) buffer solution.Results:Under optimum experimental conditions,the anodic peak current obtained by DPV was linearly dependent on SN concentration in the range of 5.0×10-7-1.0×10-4 mol·L-1.The detection limit was 2.2×10-7 mol·L-1.Conclusion:The modified electrode is inexpensive,easy to prepare with fewer sample volume and strong anti-interference and is suitable for the determination of SN in Zhengqing Fengtongning injection samples. |
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| Keywords: | sinomenine electrochemical characteristics graphene sheets-Nafion-gold nanoparticles screen-printed carbon electrodes cyclic voltammetry(CV) differential pulse voltammetry(DPV) |
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