不同介入治疗时机对颅内动脉瘤患者预后的影响

目的 探讨不同介入治疗时机对颅内动脉瘤患者预后的影响.方法 将138例颅内动脉瘤破裂患者按入院时Hunt-Hess分级分为A组(Ⅰ～Ⅲ级)109例和B组(Ⅳ～Ⅴ级)29例.所有患者均接受血管内介入栓塞治疗,按手术距发病时间不同将介入治疗时期分为早、中、晚三期,比较在不同时期接受介入治疗患者出院时的良好率、脑血管痉挛和脑积水发生率.结果 A组患者在不同时期介入栓塞治疗所获得的良好率分别为早期69.7%(23/33)、中期58.8%(10/17)和晚期61.0%(36/59),各时期比较差异无统计学意义(P>0.05),脑血管痉挛和脑积水发生率比较差异亦无统计学意义(P>0.05);B组患者早期介入栓塞治疗所获得的良好率为46.2%(6/13),明显优于晚期(0),差异有统计学意义(P<0.05);而不同时期介入栓塞治疗脑血管痉挛和脑积水发生率比较差异无统计学意义(P>0.05).结论 Hunt-Hess分级为Ⅰ～Ⅲ级的患者早、中和晚期介入治疗均可获得较为满意的预后,而Ⅳ～Ⅴ级患者应早期接受血管内介入栓塞治疗.

Influence of different interventional treatment timing on the prognosis of intracranial aneurysms

Objective To investigate the influence of different interventional treatment timing on the prognosis of patients with intracranial aneurysms. Methods One hundred and thirty-eight patients with ruptured intracranial aneurysms were divided into group A (Ⅰ- Ⅲ grade) with 109 cases and group B ( Ⅳ- Ⅴ grade) with 29 cases according to Hunt-Hess grade when admitted. All patients received interventional treatment, the operation period was divided into early, middle and late stage according to the different time from disease time to operation, then compared the good rate, cerebral vasospasm and hydrocephalus incidence of patients underwent surgery at different period. Results The good rate at different period in group A were respectively 69.7% (23/33),58.8% (10/17) and 61.0% (36/59),which and the cerebral vasospasm and hydrocephalus incidence of patients underwent surgery at different period in group A had no significant difference(P > 0.05). The good rate of patients received surgical treatment at early stage in group B was 46.2%(6/13), which was significantly superior to late stage (0), the difference was statistically significant (P < 0.05), while the cerebral vasospasm and hydrocephalus incidence of patients underwent surgery at different period in group B had no significant difference(P> 0.05). Conclusion The prognosis of patients with Hunt-Hess grade Ⅰ - Ⅲ grade undergoing interventional treatment at early, middle and late stage can be satisfactory, while grade Ⅳ - Ⅴ grade patients should receive interventional treatment at early stage.