青年早期宫颈癌患者卵巢移位术后卵巢功能的研究

目的了解青年早期宫颈癌患者在卵巢移位术后的卵巢功能。方法 2001年1月2009年12月收治53例年龄26～40岁宫颈癌Ⅰb～Ⅱa期患者,其中27例在宫颈癌根治术中行卵巢移位术为观察组,26例行宫颈癌根治术切除双侧卵巢的为对照组。术后应用血清卵泡刺激素（FSH）、黄体生成激素（LH）、雌二醇（E2）,B超及Kupper-mann评分进行卵巢功能测定,随访1～4年。结果观察组术后4年内卵巢功能基本正常,对照组术后1个月卵巢功能丧失。观察组术后4年内血FSH、LH、E2及Kuppermann评分与对照组比较有显著性意义（P〈0.05）;两组复发率比较无显著性意义（P〉0.05）。结论青年早期宫颈癌患者在宫颈癌根治术中行卵巢移位术对其卵巢功能无明显影响。

Research on Function of Ovary after Ovarian Transposition among Young Patients with Early-Stage Cervical Cancer

Objective To investigate the function of ovary after ovarian transposition among young patients with early-stage cervical cancer.Methods A total of 53young females（26-40years old）with early stage cervical cancer （FIGOⅠB orⅡA）from January 2001to December 2009.Ovarian transposition was performed at the same time of radical hysterectomy and pelvic lymphadenectomy on 27patients who were the experimental group.Radical hysterectomy and pelvic lymphadenectomy was done without ovarian transposition on other 26patients who were the control group.The function of ovarian was evaluated by serum follicle stimulating hormone（FSH）,luteinizing hormone （LH）,estradiol（E2）,the ultrasound examination and Kuppermann score system in all patients during 1-4years＇fol-low-up.Results The patients in the control group became climacteric in one month after the operation.However,among the patients in the experimental group,their normal ovarian function was preserved within 1-4years＇follow-up. There was statistically significant difference between the experimental group and the control group regarding to serum E2,FSH,LH level and Kuppermann score of the patients（P0.05）.However,there was no statistically significant difference between the two groups regarding to the recurrence rate（P0.05）.Conclusion Ovarian transposition has statistical significant effect on protection of ovarian function in young patients with early stage cervical cancer,who undergoes radical hysterectomy and pelvic lymphadenectomy.