B细胞成熟抗原在系统性红斑狼疮患者外周血单个核细胞的表达

目的检测B细胞成熟抗原（BCMA）mRNA在系统性红斑狼疮（SLE）患者外周血单个核细胞（PBMC）的表达水平,探讨BCMA在SLE发病中的意义。方法纳入2006年1-11月收治的36例SLE患者,同期17例健康志愿者作为对照组,采用半定量RT-PCR法检测外周血单个核细胞中BCMA mRNA的表达,并与SLE疾病活动指数（SLEDAI）进行相关性分析。结果 SLE患者组BCMA mRNA表达水平（0.598±0.230）均明显高于正常对照组（0.411±0.309）（P〈0.05）。SLE患者BCMA mRNA表达水平与SLEDAI评分无相关性（P=0.590）。结论 SLE患者BCMA mRNA表达水平的增高,可能在SLE的发病机制中具有一定的作用。

Expression of B-cell maturation antigen mRNA in Peripheral Blood Mononuclear Cells in Patients with Systemic Lupus Erythematosus

Objective To detect the mRNA expression of B-cell maturation antigen （ BCMA） in peripheral blood mononuclear cells （ PBMC） in patients with systemic lupus erythematosus （ SLE） ,and explore the role of BCMA in the pathogenesis of SLE. Methods From January 2006 to November 2006 the expression of BCMA mRNA in PBMC of 36 patients with SLE and 17 normal controls were measured by half-quantitative RT-PCR. The linear correlation between the expression of BCMA mRNA and SLE disease activity index （ SLEDAI） was assessed. Results The level of BCMA mRNA （ 0. 598 ±0. 230） in PBMC significantly increased in SLE patients compared with that in the normal controls （ 0. 411 ± 0. 309） （ P〈 0. 05）. The expression of BCMA mRNA in SLE patients showed no correlation with SLEDAI score （ P = 0. 590）. Conclusion The results suggest that the expression of BCMA mRNA might play an important role in the pathogenesis of SLE.