替吉奥胶囊联合奥沙利铂治疗晚期胃癌的临床观察

目的探讨替吉奥胶囊联合奥沙利铂治疗晚期胃癌的近期疗效和毒性反应。方法 2010年1-7月,16例晚期胃癌患者根据体表面积来确定初始剂量,体表面积〈1.25m2,替吉奥胶囊40mg/次,2次/d;体表面积1.25～1.5m2,替吉奥胶囊50mg/次,2次/d;体表面积〉1.5m2,替吉奥胶囊60mg/次,2次/d,早、晚饭后分别口服1次,连续服用28d,停药14d。奥沙利铂注射液130mg/m2加入5%葡萄糖注射液500mL避光缓慢静〉2h,第1、21天重复,连用2周期。按RECIST1.1标准评价客观疗效和不良反应。结果 16例患者中PR9例（56.3%）,SD3例（18.8%）,PD4例（25%）,总有效率为69.0%。不良反应主要是血液学毒性、胃肠道反应及外周神经毒性,且均在Ⅰ～Ⅱ。结论替吉奥胶囊联合奥沙利铂方案治疗晚期胃癌的近期疗效较好,不良反应可以耐受,值得进一步研究应用。

Clinical Observation of Oxaliplatin Combined With S1Capsule for Advanced Gastric Cancer

Objective To explore the early efficacy of Oxaliplatin combined with S1capsule on advanced gastric cancer and observe the toxicity.Methods A total of 16patients with advanced gastric cancer from January to July 2010were treated with chemotherapy：oxaliplatin 130mg/m2 mixed with 5%glucose injection 500mL in the first day and repeated in the 21st day;Po after breakfast and dinner：S1capsule with an initial dose according to the body surface area.Body surface1.25m2,40mg once,twice per day;body surface：1.25-1.5m2,50mg once,twice per day;body surface1.5m2,60mg once,twice per day.The medication lasted for 28days,withdrew for 14days. All of the patients underwent the treatment for two cycles.Efficacy and toxicities were evaluated according to the RECIST 1.1standard.Results Of the 16patients,partial remission（PR）was in nine（56.3%）,stable disease was in three（18.8%）（SD）,and progression disease was in four（PD）.The total response rate was 69.0%.The major toxicities included leucopenia,nausea,vomiting and neurosensory abnormity.Conclusion Oxaliplatin combined with S1capsule is effective on advanced gastric cancer,and the adverse effects are tolerable.