盐酸丁咯地尔治疗耳鸣的随机对照研究

目的探讨盐酸丁咯地尔对主观性耳鸣的治疗效果。方法将2006年1月2008年1月收治的91例患者随机分为丁咯地尔组（治疗组）和维生素B1组（对照组）,治疗组46例58只耳,对照组45例52只耳,分别以丁咯地尔及维生素B1治疗1个月后,对两组患者耳鸣治疗有效率进行χ2检验。结果治疗组有效17例,显效16例,无效12例,加重1例,有效率71.7%（33/46）;对照组有效12例,显效7例,无效25例,加重1例,有效率42.2%（19/45）。两组比较有统计学意义（P〈0.05）。结论丁咯地尔对缓解耳鸣有一定作用。

Therapeutic Efficacy of Buflomedil Hydrochloride on Tinnitus

Objective To investigate the clinical effect of buflomedil hydrochlorideis on tinnitus.Methods A randomized,doubled-blind,and controlled clinical trials was conducted from January 2006to January 2008.Ninty-one patients were divided into two groups randomly：the treatment group and controlled group（placebo group）.After being evaluated by tinnitus questionnaire,the two groups were treated with buflomedil hydrochloride and vitamine B1respectively.One month after treatment,the efficacy of the two groups was observed.The data was analyzed byχ2 test. Results The efficacy was 71.7%in the treatment group and 42.2%in the controlled group,with a significant difference between the two groups（P0.05）.Conclusion Buflomedil hydrochloride is effective on tinnitus.