雷公藤加丹参治疗儿童紫癜性肾炎疗效分析

目前国内外对小儿紫癜性肾炎尚无肯定有效的治疗方法。本文报道试用雷公藤多甙加丹参治疗,同时设立单用雷公藤多甙治疗对照组。治疗结果表明:治疗组对消除患儿水肿、降低血压的平均时间,对血尿、尿蛋白、尿C_3等的转阴平均时间和甲皱微循环恢复正常的平均时间,均显著优于对照组。

Treatment of Purpuric Nephritis in Children with Tripterygium Wilfordii and Radix Salviae Miltiorrhizae

This paper dealt with the data of Tripterygium wilfordii polyoglucoside (1 mg/kg.d) combined with Radix Salvaie multiorrhizae (6-15 g/d) for treating purpuric nephritis (group-A), compared with the control group of using Tripterygium wilfordii polyoglucoside treatment only (group-B). The average time of edema-disappearing and blood pressure-resuming to normal range were 8.72 +/- 3.07 and 7.44 +/- 5.17 days in group-A, which were much better than those in group-B (P < 0.05). The average time of blood urine-disappearing in group-A and group-B were 36.37 +/- 11.50 and 47.73 +/- 14.03 days respectively. The average time on C3 in the urine resumed to normal in groups A and B were 40.33 +/- 4.51 and 50.00 +/- 5.30 days respectively (P < 0.01). The time of microcirculation of nail fold returned to normal after treatment in group-A and group-B were 39.00 +/- 11.03 and 66.00 +/- 9.01 days respectively (P < 0.001). These results indicated that the effect of group-A was much better than that of group-B.