| 一氧化氮供体型非甾体抗炎药抗肿瘤作用机制研究现状 |
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| 引用本文： | 静永旺,袁胜涛,张陆勇. 一氧化氮供体型非甾体抗炎药抗肿瘤作用机制研究现状[J]. 药学进展, 2008, 32(12): 543-547 |
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| 作者姓名： | 静永旺 袁胜涛 张陆勇 |
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| 作者单位： | 中国药科大学江苏省新药筛选中心,江苏,南京,210009 |
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| 摘 要： | 概述一氧化氮供体型非甾体抗炎药（NO—NSAIDs）抗肿瘤药理学实验研究，着重综述该类药物抗肿瘤作用机制研究进展。在NO-NSAIDs中，NO-阿司匹林被研究得最为深入，其有多种作用机制，包括阻断Wnt信号通路、抑制NF-κB的激活、抑制一氧化氮合酶、调控环氧合酶-2、调节Keapl-Nrf2和MAPK信号通路等，这些机制可能在该类药物的抗癌作用中扮演着不同角色。
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| 关 键 词： | 非甾体抗炎药 一氧化氮供体 抗肿瘤活性 作用机制 细胞信号通路 |
Antitumor Mechanism of NO-NSAIDs:Current Status |
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| JING Yong-wang,YUAN Sheng-tao,ZHANG Lu-yong. Antitumor Mechanism of NO-NSAIDs:Current Status[J]. Progress in Pharmaceutical Sciences, 2008, 32(12): 543-547 |
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| Authors: | JING Yong-wang YUAN Sheng-tao ZHANG Lu-yong |
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| Affiliation: | JING Yong-wang,YUAN Sheng-tao,ZHANG Lu-yong(Jiangsu Center for Drug Screening,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | The experimental studies on antitumor pharmacology of nitric oxide-donating non-steroidal anti-inflammatory drugs（NO-NSAIDs） were outlined. The advances in the antitumor mechanism of NO- NSAIDs were emphatically reviewed. NO-aspirin, the best-studied NO-NSAID, has been shown to possess multiple mechanisms of action, including blockade of Wnt signaling pathway, inhibition of activation of NF-KB, inhibition of nitric oxide synthase （NOS）, modulation of cyclooxygenase -2 （ COX-2）, and regulation of Keapl-Nrf2 and MAPK signaling pathways. These mechanisms might play varied roles in antitumor activity of NO-NSAIDs. |
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| Keywords: | NSAID Nitric oxide donor Antitumor activity Mechanism of action Cell signaling pathway |
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