| 复方牛蒡子含片水提工艺优选与牛蒡子苷含量变化研究 |
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| 引用本文： | 段晓颖,张辉,张明艳. 复方牛蒡子含片水提工艺优选与牛蒡子苷含量变化研究[J]. 中国现代应用药学, 2010, 27(6): 499-501 |
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| 作者姓名： | 段晓颖 张辉 张明艳 |
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| 作者单位： | 1.河南中医学院第一附属医院中药制剂实验室，郑州 450000；2.河南省医药学校，河南 开封 475001 |
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| 基金项目： | 河南省科技攻关项目（0524420029） |
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| 摘 要： | 目的优选复方牛蒡子含片最佳水煎工艺,并考察各工艺步骤中牛蒡子苷的含量变化情况。方法以牛蒡子苷提取量为指标,采用正交试验优选影响水煎工艺的主要因素,并对水煎浓缩液、醇沉液及干浸膏中牛蒡子苷进行含量测定。结果优选出牛蒡子最佳水煎工艺为加水12倍,煎煮3次,每次1h,牛蒡子苷在各工艺步骤均有一定量损失。结论本实验为复方牛蒡子含片的生产提供了可靠数据。
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| 关 键 词： | 复方牛蒡子含片 正交试验 高效液相色谱法 牛蒡子苷 |
Optimizing Decoction Process for Compound Niubangzi Buccal Tablets and Studies on the Content Changes of Arctiin |
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| DUAN Xiaoying,ZHANG Hui,ZHANG Mingyan. Optimizing Decoction Process for Compound Niubangzi Buccal Tablets and Studies on the Content Changes of Arctiin[J]. The Chinese Journal of Modern Applied Pharmacy, 2010, 27(6): 499-501 |
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| Authors: | DUAN Xiaoying ZHANG Hui ZHANG Mingyan |
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| Affiliation: | 1.Laboratory of China Mater Med Preparation for The First Affiliated Hospital Henan College of TCM, Zhengzhou 450000,China; 2.The Pharmacology School of Henan Province, Kaifeng 475000, China |
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| Abstract: | OBJECTIVE To optimize the decoction technology for compound niubangzi buccal tablets, and observe the content changes of arctiin in all process steps. METHODS Taking extraction amount as guide, using orthogonal test to optimize the main factors affected the decoction process, determining the arctiin contents in concentrated decoction liquid, alcohol precipitation solution and dry extract. RESULTS The optimum condition was adding 12 times amount of water, decocted for three times and each time for 1 hour. There was some loss of arctiin in each process step. CONCLUSION The experiment provided reliable data for the production of compound Niubangzi buccal tablets. |
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| Keywords: | compound Niubangzi buccal tablets orthogonal test HPLC arctiin |
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