| 胆管癌中EGFR、nm23H1基因表达及其意义 |
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| 引用本文： | 周彦明,李玉民,曹农. 胆管癌中EGFR、nm23H1基因表达及其意义[J]. 中国现代普通外科进展, 2002, 5(3): 172-173 |
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| 作者姓名： | 周彦明 李玉民 曹农 |
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| 作者单位： | 兰州医学院第一附属医院普外科,甘肃,兰州,730000 |
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| 摘 要： | 目的：探讨表皮生长因子受体（EGFR）和肿瘤转移抑制基因nm23H1在胆管癌的表达及其意义。方法：采用免疫组化SABC法检测21例胆管癌及15例胆管炎组织中EGFR，nm23H1基因蛋白产物，并分析其意义。结果：胆管癌中nm23H1阳性表达率低于胆管炎组织（P＜0．05），而EGFR在胆管癌组织中的阳性表达率则显升高（P＜0．01），nm23H1的表达与胆管癌TNM分期呈负相关（P＜0．01）。结论：EGFR的高表达和nm23H1的低表达参与胆管癌的发生，发展。
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| 关 键 词： | 胆管癌 受体 表皮生长因子 尿抑胃素 nm23H1 基因表达 临床意义 |
| 文章编号： | 1009-9905(2002)03-0172-02 |
| 修稿时间： | 2002-04-25 |
Expression and significance of EGFR,gene nm23H1 in cholangiocarcinoma |
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| ZHOU Yan ming,LI Yu min,CAO Nong. Expression and significance of EGFR,gene nm23H1 in cholangiocarcinoma[J]. Chinese Journal of Current Advances in General Surgery, 2002, 5(3): 172-173 |
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| Authors: | ZHOU Yan ming LI Yu min CAO Nong |
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| Affiliation: | ZHOU Yan ming,LI Yu min,CAO NongDepartment of General Sergery,The First Affiliated Hospital of Lanzhou Medical College |
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| Abstract: | Objective:To evaluate the expression of EGFR and gene nm23H1 and their relation to the tumor oncogenesis and progress of cholangiocarcinoma.Methods:SABC immunohistochemistry was used to detect the expression of EGFR and nm23H1 in cholangiocarcinoma and cholangitis tissue.Results:The positive rate of nm23H1 in cholangiocarcinoma was lower than cholangitis(P<0.05),while that of EGFR increased significantly(P<0.05).The expression of nm23H1 was negtive related to tumor TNM stage (P<0.05).Conclusion:It is suggested that over expression of EGFR and lower expression of nm23H1 is involved in the oncogenesis and progress of cholangiocarcinoma |
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| Keywords: | Bile duct neoplasms Receptors epidermal growth factor urogastrone Gene nm23H1 Gene expression |
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