| RP-HPLC法测定盐酸恩丹西酮氯化钠注射液的含量 |
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| 引用本文： | 邱瑞桂,王世会. RP-HPLC法测定盐酸恩丹西酮氯化钠注射液的含量[J]. 药学实践杂志, 2002, 20(3): 179-181 |
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| 作者姓名： | 邱瑞桂 王世会 |
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| 作者单位： | 解放军413医院药剂科,舟山,316000 |
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| 摘 要： | 目的：建立反相高效液相色谱法测定盐酸恩丹西酮氯化钠注射液含量的方法。方法：采用ODS反相柱，流动相为甲醇-0.02M磷酸二氢钾（58：42，pH=6.0),检测波长为308nhm。结果；盐酸昂丹司琼在辅料中的回收率为100.14%。日内与日间精密度分别为0.41%和0.54%。结论：本法准确，快捷，适用于测定盐酸恩丹西酮氯化钠注射液的含量。
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| 关 键 词： | RP-HPLC法 盐酸恩丹西酮 氯化钠注射液 反相高效色谱法 含量测定 |
| 文章编号： | 1006-0111(2002)03-0179-03 |
| 收稿时间： | 2002-01-14 |
| 修稿时间： | 2002-01-14 |
Determination of ondansetron hydrochloride in natrium chloride infusion by a reversed-phase high performance liquid chromatography |
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| QIU Rui-gui and WANG Shi-hui. Determination of ondansetron hydrochloride in natrium chloride infusion by a reversed-phase high performance liquid chromatography[J]. The Journal of Pharmaceutical Practice, 2002, 20(3): 179-181 |
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| Authors: | QIU Rui-gui and WANG Shi-hui |
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| Affiliation: | Department of Pharmacy, No.413 Hospital, Zhoushan 316000, China;Department of Pharmacy, No.413 Hospital, Zhoushan 316000, China |
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| Abstract: | OBJECTIVE To establish a new method to determin ondansetron in a natrium chloride infusion.METHLDS A reversed phase high performance liquid chromatography was employed. The mobile phase was composed of methanol and 0.02M KH2PO4 solution(58:42,pH=6.0).ODS was the stable phase.RESULTS Recovery was 100.14%.Between-day and Within-day precision was 0.41% and 0.54% respectively.CONCLUSION The method was rapid and correct.It is suitable for the determination of ondansetron in natrium chloride infusion. |
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| Keywords: | ondansetron determination RP HPLC |
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